SURVEY STUDY FOR VEHICULAR AD HOC NETWORKS PERFORMANCE IN CITY AND URBAN RESIDENTIAL AREAS

This thesis it survey study for VANET (Vehicular Ad-Hoc Networks) and it performance in city and urban residential areas, when the the number of vehicles on roads is increasing annually, due to the higher amount of traffic, there are more accidents associated with road traffic complexity. VANET can be used to detect dangerous situations which are forwarded to the driver assistant system by monitoring the traffic status.fi=Opinnäytetyö kokotekstinä PDF-muodossa.|en=Thesis fulltext in PDF format.|sv=Lärdomsprov tillgängligt som fulltext i PDF-format

Topological dyonic Taub-Bolt/NUT-AdS: Thermodynamics and first law

Motivated by the absence of Misner string in the Euclidean Taub-Bolt/NUT solutions with flat horizons, we present a new treatment for studying the thermodynamics of these spactimes. This treatment is based on introducing a new charge, $N=\sigma \, n$ (where $n$ is the nut charge and $\sigma$ is some constant) and its conjugate thermodynamic potential $\Phi_N$. Upon identifying one of the spatial coordinates, the boundary of these solutions contains two annulus-like surfaces in addition to the constant-r surface. For these solutions, we show that these annuli surfaces receive electric, magnetic and mass/energy fluxes, therefore, they have nontrivial contributions to these conserved charges. Calculating these conserved charges we find, $Q_e = Q^{\infty}_e-2N\Phi_m$, $Q_m =Q^{\infty}_m+2N\Phi_e$ and $\mathfrak{M} =M-2N\Phi_N$, where $Q^{\infty}_e$, $Q^{\infty}_m$, $M$ are electric charge, magnetic charge and mass in the $n=0$ case, while $\Phi_e$ and $\Phi_m$ are the electric and magnetic potentials. The calculated thermodynamic quantities obey the first law of thermodynamics while the entropy is the area of the horizon. Furthermore, all these quantities obey Smarr's relation. We show the consistency of these results through calculating the Hamiltonian and its variation which reproduces the first law.Comment: 22 pages, one figur

Effects of a Group E-Therapy Program on Improving Social Skills of Children with ASD

The purpose was to investigate the effectiveness of a group E-therapy program on improving children's social skills with ASD. Participants were (16) children between the ages of Six and eleventh. A pre-post design was used to examine the effectiveness of group therapy on developing social skills in children with Autism. Stone's social skills Scale was administered to assess children's social skills with autism spectrum disorder as a pre-post-test. The group therapy strategies were performed on the experimental group by their actual teacher during an exact 8-week lesson period with 50-minute sessions three times per week. The Z-value results for the differences in the mean post-test scores between the experimental and control groups in social skills. The table shows that the value of (Z) ranged between (2.809 - 3.354). These values are significant at (0.01) level in favor of the experimental group. The value of (Z) in Table 2 ranged between (2.617 - 2.711), which are significant values at the level (0.01). This indicates that group therapy had a positive effect on social skills in children with ASD

ENHANCEMENT OF LORNOXICAM SOLUBILITY BY INCLUSION COMPLEXATION WITH CYCLODEXTRIN: PREPARATION AND CHARACTERIZATION

Objective: Lornoxicam is a potent anti-inflammatory drug which has analgesic and antipyretic properties. It is water-insoluble powder. The inclusion complexes of lornoxicam (LOR) with β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPCD) were prepared and characterised in order to improve the solubility of the drug and enhance its bioavailability.Methods: Complexes were prepared by physical mixing and freeze-drying in three different drug/polymer ratios (1:1, 1:2 and 3:2). The solid complexes were characterised through differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray diffraction, nuclear magnetic resonance (NMR) spectroscopy, and Fourier transformed infrared (FTIR) spectroscopy.Results: The data showed that LOR may be complexed with cyclodextrin (CD) forming soluble complexes. The lyophilized 1:2 LOR/HPCD complex is the most soluble.Conclusion: Solubility increases with lyophilization than with physical mixing and by the use of HPCD than βCD in complexation

Egyptian consensus on treat-to-target approach for osteoporosis: a clinical practice guideline from the Egyptian Academy of bone health and metabolic bone diseases

Background: This study was carried out to achieve an Egyptian expert consensus on a treat-to-target managementstrategy for osteoporosis using Delphi technique. A scientific committee identified researchers and clinicians with expertise in osteoporosis in Egypt. Delphi process was implemented (2 rounds) to establish a consensus on 15 clinical standards: (1) concept, (2) diagnosis, (3) case identification, (4) whom to treat, (5) who should treat?, (6) case stratification and intervention thresholds, (7) falls risk, (8) investigations, (9) treatment target, (10) management, (11) optimum treatment duration, (12) monitoring, (13) drug holiday, (14) osteoporosis in men, and (15) post-fracture care and fracture liaison service. Results: The surveys were sent to an expert panel (n = 25), of whom 24 participated in the two rounds. Respondents were drawn from different governorates and health centres across Egypt including the Ministry of Health. Most of the participants were rheumatologists (76%), followed by internists (8%), orthopaedic doctors (4%), rehabilitation doctors (4%), primary care (4%), and ortho-geriatrics (4%) physicians. Seventy-two recommendations, categorised into 15 sections, were obtained. Agreement with the recommendations (rank 7–9) ranged from 83.4 to 100%. Consensus was reached (i.e. ≥ 75% of respondents strongly agreed or agreed) on the wording of all 15 clinical standards identified by the scientific committee. An algorithm for the management of postmenopausal osteoporosis has been suggested. Conclusion: A wide and representative panel of experts established a consensus regarding the management of osteoporosis in Egypt. The developed guidelines provide a comprehensive approach to the assessment and management of osteoporosis for all Egyptian healthcare professionals who are involved in its management

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

AbstractDevelopmental epileptic encephalopathies are devastating disorders characterized by intractable epileptic seizures and developmental delay. Here, we report an allelic series of germline recessive mutations in UGDH in 36 cases from 25 families presenting with epileptic encephalopathy with developmental delay and hypotonia. UGDH encodes an oxidoreductase that converts UDP-glucose to UDP-glucuronic acid, a key component of specific proteoglycans and glycolipids. Consistent with being loss-of-function alleles, we show using patients’ primary fibroblasts and biochemical assays, that these mutations either impair UGDH stability, oligomerization, or enzymatic activity. In vitro, patient-derived cerebral organoids are smaller with a reduced number of proliferating neuronal progenitors while mutant ugdh zebrafish do not phenocopy the human disease. Our study defines UGDH as a key player for the production of extracellular matrix components that are essential for human brain development. Based on the incidence of variants observed, UGDH mutations are likely to be a frequent cause of recessive epileptic encephalopathy.</jats:p